There is no "if" about it. Only the illiterate deny it. The Holy Spirit is not the only thing that will depart a man.
Holy Spirit Departing From Saul
Not only the Holy Spirit, but God Himself had also departed from Saul (
1Sam. 18:12). The same was true of Samson -- God departed from him (
Judg. 16:20).
Six Divine Things Can Depart From Man:
1. God Himself (
1Sam. 18:12;
28:15-16;
Judg. 16:20;
Hos. 9:12)
2. The Holy Spirit (
1Sam. 16:14;
Ps. 51:11)
3. God's glory (
1Sam. 4:21-22;
Ezek. 10:18)
4. God's Word (
Dt. 4:9;
Prov. 3:21;
4:21;
Heb. 2:1, notes)
5. God's soul (
Jer. 6:8;
Heb. 10:38-39)
6. God's mercy (
2Sam. 7:15)
Dake's Annotated Reference Bible.
Transfer of Spirits
In contrast with the Spirit of the Lord coming upon David from that day forward (
1Sam. 16:13), the same Holy Spirit departed from Saul, and an evil spirit troubled him (
1Sam. 16:14). This is evidence again that one who returns to sin may lose the Holy Spirit. Saul lost Him after having Him on his life for several years (
1Sam. 10:6,
9-13;
11:6;
13:1). David believed such was possible, for he prayed for God not to take the Spirit from him (
Ps. 51:11). Lucifer, fallen angels, demons, Adam and Eve, and many others are examples of sin causing one to lose what he has been given by the Lord.
Dake's Annotated Reference Bible.